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New Medicine

Financial Express

The much popular low on carbs, the keto diet is not just the way to a great body and weight loss, researchers suggest it also kills pancreatic cancer cells when combined with a triple-drug therapy. The findings of the study published in the journal 'Med' says that following a ketogenic diet decreases the supply of glucose in the pancreatic tumour, making cancer cells to starve to death. The diet also elevated ketone bodies produced by the liver can put additional stress on the tumour.

The Times of India

Conventional diagnosis of breast cancer involves the histological and immunohistochemical analysis of tissue sections obtained through clinical biopsy. For surgical margin assessment within the operating room, the standard technique is frozen section examination, which takes between 30 minutes to two hours to give results. Now, a team of IISc scientists has developed a technology for rapid and label-free diagnosis. Technologies for rapid and label-free diagnosis of malignancies from breast tissues have significant potential for application in pathology laboratories and operating rooms. The team led by Prof Annapoorni Rangarajan and Prof Hardik J Pandya from IISc along with researchers from Assam Medical College, reports the design, development, and clinical validation of a Microelectromechanical systems-based (MEMS-based) platform for characterisation of ex vivo breast biopsy tissues to classify them as tumour or normal.

Global coverage

Scrip Pharma Intelligence

A missed primary endpoint in new top-line results from a Japanese trial with the stem cell therapy for stroke MultiStem hits Athersys and Japanese partner hard, casting a shadow over ongoing studies.

Pharma Biz

Pfizer Inc. announced detailed results from two pivotal studies that make up the ELEVATE UC phase 3 registrational programme evaluating etrasimod, a once-daily, oral, selective sphingosine 1-phosphate (S1P) receptor modulator for the treatment of moderately-to-severely active ulcerative colitis (UC). These data were presented as a late-breaker presentation (abstract number 968a) at Digestive Disease Week (DDW) 2022.

Pharma Biz

In Eli Lilly and Company's pivotal, phase 3 LUCENT-2 study, patients with ulcerative colitis (UC) who responded to mirikizumab at 12 weeks achieved and maintained statistically superior and clinically meaningful improvements at one year compared to placebo across the primary endpoint of clinical remission and all key secondary endpoints, including bowel urgency severity, using a novel, patient-reported outcome measure.

Fierce Biotech

As Monkeypox cases keep getting reported globally, the Moderna Inc has informed that they are testing potential vaccines against monkeypox in pre-clinical trials. The Cambridge, Massachusetts biopharma, responsible for one of the most effective Covid-19 vaccines on the market, announced plans to explore potential vaccines for monkeypox at a “preclinical level," according to a Monday announcement.

Financial Post

Biohaven Pharmaceutical said on Monday a late-stage trial of its drug against spinocerebellar ataxia, a genetic neurological disease, failed to meet the main goal of the study. Spinocerebellar ataxia is a progressive disorder that causes symptoms such as uncoordinated movement, difficulties swallowing and muscle wasting.

US News

Pfizer on Monday reported that a third COVID-19 vaccine dose in children under the age of 5 produced a “strong” immune response. The company, along with its partner BioNTech, reported that the three-dose series for kids six months to 5 years old was 80 percent effective at preventing symptomatic infection during the omicron wave.

Pharma Biz

Nanomix Corporation, a leader in the development of mobile, affordable, point-of-care diagnostics, announced that it has received the CE mark for its eLab Covid-19 rapid antigen test. The Covid-19 antigen test cartridge is used with the Nanomix eLab Analyzer to provide qualitative results in 15 minutes from an anterior nasal swab.

Pharma Biz

Birmingham scientists have shown an existing drug may reduce damage after spinal cord injury, by blocking the inflammatory response in the spinal cord.

Doctors & Hospitals

Aftab News

AIIMS Bhubaneswar will start kidney transplantation surgery from July. The institution has already received permission from the Directorate of Medical Education and Training (DMET) of the state government to start the procedure. Sachidananda Mohanty, medical superintendent of AIIMS Bhubaneswar, said they have a complete setup in the hospital to start kidney transplant. “DMET has given approval for this and we have trained manpower for the procedure. We are expecting our first case by July 15,” he added. He said doctors from two departments — nephrology and urology — will play vital roles in the surgeries.

News Drum

Some of India's hospitals are set to upgrade the quality of their services leveraging space technology in emergency care and critical care departments thanks to ISRO. Many healthcare associations approached ISRO in 2016 to learn the best practices in its quality domain and implement them in their emergency care and critical care departments "for reducing mortality rates." They included Association of Healthcare Providers (India) (AHPI), Indian Society of Critical Care Medicine (ISCCM), Society for Emergency Medicine India (SEMI), and the Consortium of Accredited Healthcare Organisations (CAHO), according to ISRO (Indian Space Research Organisation).

Express Healthcare

Human body is an engineering marvel and like any other machine, the efficiency of the human body decreases with age. The skeletal system is no exception to it and our bones get weaker with age making them prone to fractures. Osteoporosis is a disease that fast forwards the bone weakening and people with this condition are more likely to get spinal fractures. Dr Manish Vaish, Director Neurosurgery, Max Super-Specialty Hospital, Vaishali, Ghaziabad, says, "Osteoporosis is a medical condition in which there is a continuous weakening of bones without any visible symptoms until there is a fracture. Osteoporosis most commonly results in spinal fractures which are also known as vertebral compression fractures. Approximately 17.9 percent of people above 50 years of age suffer from vertebral fractures."

The Times of India

Lok Nayak Hospital has become the first Delhi government-run facility to install a urodynamic video system, which is an essential machine used for diagnosing and treating urological conditions in children up to 12 years of age. The system can also be used to diagnose and treat other gastrointestinal diseases, such as measuring the pressure of the anal canal and oesophagus. At present, there are only a few centres in the country with such equipment. On Wednesday, health minister Satyendar Jain inaugurated the system and said this would help doctors in detecting the condition at an early stage in children, which can prevent serious complications later in life. "Diagnosis and treatment at an early stage not only saves a patient's money, but also their life. Late diagnosis leads to serious health conditions and the treatment becomes expensive," he added.

The Tribune

The tenure of Dr Randeep Guleria as the director of the All India Institute of Medical Sciences (AIIMS) here has been extended by three months, according to an office memorandum issued by the premier hospital. Guleria's current term is scheduled to end on Thursday (March 24). He was appointed as the director of AIIMS, New Delhi for a term of five years on March 28, 2017. "He will complete his tenure on 24.03.2022. President, AIIMS is pleased to extend his tenure w.e.f. March 25, 2022 by three months or by the time new director is appointed, whichever is earlier," the office memorandum issued by the hospital on Tuesday said. Other terms and conditions of Guleria's appointment would be in accordance with the rules of the institute, it added.

Drug Discovery

Express Pharma

Results from the Deliver and DAPA-HF phase-III trials demonstrate Dapagliflozin’s efficacy in heart failure regardless of ejection fraction. High-level results from the Deliver phase-III trial showed AstraZeneca’s Dapagliflozin reached a statistically significant and clinically meaningful reduction in the primary composite endpoint of Cardio Vascular (CV) death or worsening Heart Failure (HF). The trial was conducted in patients with HF with mildly reduced or preserved ejection fraction (defined as Left Ventricular Ejection Fraction [LVEF] greater than 40 percent), AstraZeneca said in a statement.

Financial Express

The high-level results from the DELIVER Phase III trial released on Monday show that AstraZeneca’s dapagliflozin has reached a statistically significant and clinically meaningful reduction in the primary composite endpoint of cardiovascular (CV) death or worsening heart failure (HF).

Financial Express

According to a new study, the most efficient vehicle for absorbing vitamin D is milk and water. Multiple health issues have been linked with Vitamin D insufficiency, including immune response to Covid-19 and estimates have shown that about 40 percent of the European population could be suffering from vitamin D deficiencies, while at least 13 percent suffer from severe vitamin D deficiency. Therefore Vitamin D supplements are vital and understanding whether they will be absorbed and how best to aid absorption is also crucial.

The Economic Times

A team of scientists said Wednesday they had developed an oral male contraceptive that is 99 percent effective in mice without causing side effects, and could enter human trials by the end of this year. The findings will be presented at the American Chemical Society's spring meeting, and mark a key step towards expanding birth control options -- as well as responsibilities -- for men. Ever since the female birth control pill was first approved in the 1960s, researchers have been interested in a male equivalent, Md Abdullah Al Noman, a graduate student at the University of Minnesota who will present the work, said.
 

Becares-Weekly

Live Mint

Hyderabad-based pharmaceuticals and biologics major Biological E Ltd has priced its Corbevax anti-Covid vaccine at ₹990 (inclusive of taxes and vaccine administration charges) in the private market, and ₹145 for the government vaccination programme, news agency PTI quoted the firm's managing director Mahima Datla as saying.  Currently, the vaccine is being used for the inoculation of children in the 12 to 14 age group. In view of this, the company has also expressed confidence over getting emergency use authorisation for use of its vaccine in children in the age group of 5-12 years. Biological E said its multiple manufacturing units in Hyderabad are fully qualified to enable the production of around 1 billion dosages of Corbevax annually and it is geared up to meet any increase in demand.

Live Mint

Biological E Limited's Corbevax is being administered to children in the age group 12-14 in India. This age group got the Indian government's nod to be receive vaccine against the novel coronavirus from 16 March, Wednesday. These children have to register for getting the vaccine on the CoWIN portal. India's third indigenous anti-Covid vaccine has been manufactured by Hyderabad-based Biological E Limited. Biological E has supplied 5 crore doses of Corbevax to the Centre, which has then distributed the same to states.

Live Mint

Biological E seems confident regarding getting emergency use authorisation for use of its COVID vaccine Corbevax among children in the age group of 5-12 years. Currently, the vaccine is inoculated among children in the age group of 12 to 14 years The Hyderabad-based company Is qualified to produce around 1 billion dosages of Corbevax annually and it is geared up to meet any increase in demand. Currently, the company has produced 30 crore vaccines as part of its commitment made to the Government of India, with 5 crore dosages already supplied.

The Indian Express

Biotech firm Biological E. Limited is geared to facilitate the first phase of the vaccination drive for the 12-15 age group and is ready with 30 crore doses of which five crore has been rolled out to 17 different sites in the country, said a top official of the firm. "This is the most affordable COVID-19 vaccine for the Government of India which is providing free vaccination to all eligible citizens. The pricing of CORBEVAX in the private market will be Rs 800 (and inclusive of all taxes and vaccine administration charges will cost Rs 990) The vaccine is being sold at Rs 145 per dose to the government," Mahima Datla, managing director of Biological E. Limited said at a virtual media interaction on Wednesday. "We have an annual production capacity upto one billion vaccines," Datla said. The firm collaborated with the Texas Children's Hospital and the Baylor College to develop Corbevax vaccine. Dynavax, Inc from USA supported Corbevax development by providing the adjuvant and THSTI Delhi conducted key immunogenicity testing as part of a comprehensive clinical trial development plan.

The Times of India

Only about 3,800 children aged between 12 and 14 were vaccinated against Covid-19 in the city on Wednesday, the first day of vaccination for this cohort in the country. All the children were administered Corbevax, India's first indigenously developed protein subunit vaccine against Covid-19, made by Biological E. Each dose in the private market will cost Rs 800 per dose, excluding GST, and around Rs 990, including taxes and administration charges. For the government, the price will be Rs 145. There are nearly 6.2 lakh children in this age group in Delhi who are eligible for the vaccine. Hospital officials said the first day saw a lukewarm response; footfall is expected to pick up after Holi.

Medical Specialties

Financial Express

The much popular low on carbs, the keto diet is not just the way to a great body and weight loss, researchers suggest it also kills pancreatic cancer cells when combined with a triple-drug therapy. The findings of the study published in the journal 'Med' says that following a ketogenic diet decreases the supply of glucose in the pancreatic tumour, making cancer cells to starve to death. The diet also elevated ketone bodies produced by the liver can put additional stress on the tumour.

The Times of India

Conventional diagnosis of breast cancer involves the histological and immunohistochemical analysis of tissue sections obtained through clinical biopsy. For surgical margin assessment within the operating room, the standard technique is frozen section examination, which takes between 30 minutes to two hours to give results. Now, a team of IISc scientists has developed a technology for rapid and label-free diagnosis. Technologies for rapid and label-free diagnosis of malignancies from breast tissues have significant potential for application in pathology laboratories and operating rooms. The team led by Prof Annapoorni Rangarajan and Prof Hardik J Pandya from IISc along with researchers from Assam Medical College, reports the design, development, and clinical validation of a Microelectromechanical systems-based (MEMS-based) platform for characterisation of ex vivo breast biopsy tissues to classify them as tumour or normal.

Vaccine Launch & Research

Odisha TV

In a breakthrough, US scientists have started a trial on a vaccine that will protect people from developing pancreatic cancer. A team at Johns Hopkins University in the US administered the first preventive jab in a woman with a family history of the disease, Daily Mail reported. They aim to involve 25 healthy volunteers at high risk of pancreatic cancer with genetic history.

The Print

An India-made cervical cancer vaccine would be available by November when Serum Institute of India launches its Quadrivalent Human Papillomavirus inoculation.

Business Standard

Moderna's COVID-19 vaccine works in babies, toddlers and preschoolers the company announced Wednesday -- and if regulators agree it could mean a chance to finally start vaccinating the littlest kids by summer. Moderna said in the coming weeks it would ask regulators in the U.S. and Europe to authorize two small-dose shots for youngsters under 6. The company also is seeking to have larger-dose shots cleared for older children and teens in the U.S. The nation's 18 million children under 5 are the only age group not yet eligible for vaccination. Competitor Pfizer currently offers kid-sized doses for school-age children and full-strength shots for those 12 and older.

Business Standard

The Drugs Controller General of India (DCGI) granted permission on Wednesday for conducting the phase-3 clinical trial of COVID-19 vaccine Covovax as a booster dose in adults, official sources said. The Subject Expert Committee (SEC) on COVID-19 of the Central Drugs Standard Control Organisation (CDSCO) had, on March 5, recommended permission for conducting the phase-3 clinical trial for Covovax as a booster dose in adults who have been fully vaccinated with either Covaxin or Covishield at least three months ago. The DCGI approved Covovax for restricted use in emergency situations in adults on December 28 last year and for inoculating the beneficiaries in the 12-17 years age group, subject to certain conditions, on March 9.

Financial Express

The Drugs Controller General of India (DCGI) has granted emergency use authorisation (EUA) for the Novavax and Serum Institute of India (SII) Covid-19 vaccine, Covovax, in the 12-18 age group. Covovax is the fourth vaccine to receive EUA from the DCGI for use among adolescents 12 and older. The Novavax vaccine is manufactured and marketed in India by SII under the brand name, Covovax. Novavax has a partnership with SII to source one billion doses of the vaccine. SII has already supplied close to 40 million doses of Covovax to Europe and Australia. "The approval of Covovax for adolescents 12 and older in India marks another significant milestone in strengthening our immunisation efforts across India and low and middle income countries," Adar Poonawalla, CEO, SII said.

Business Standard

The Centre's recent move to reduce the gap between two Covishield doses to 8-16 weeks from the earlier gap of 12-16 weeks may help liquidate vaccine stocks faster. Covishield maker Serum Institute of India (SII) is sitting on 200-250 million doses of the vaccine at its Pune facility. The administration of Covishield at a reduced gap of 8 weeks has not started yet. However, this would create a faster turnaround of stocks lying with the government and private hospitals, thereby leading to a liquidation of the inve­ntory lying with the company.

Disease Studies

The Free Press Journal

Monkeypox virus is not as contagious or severe as COVID-19, however, its spread is a matter of concern, Dr NK Arora, Chairman of the COVID-19 working group of the National Technical Advisory Group on Immunisation (NTAGI), said on Wednesday. He said the Centre has set up an expert committee for this.

NY Post

New U.S. research on long COVID-19 provides fresh evidence that it can happen even after breakthrough infections in vaccinated people, and that older adults face higher risks for the long-term effects. In a study of veterans published Wednesday, about one-third who had breakthrough infections showed signs of long COVID. A separate report from the Centers for Disease Control and Prevention found that up to a year after an initial coronavirus infection, 1 in 4 adults aged 65 and older had at least one potential long COVID health problem, compared with 1 in 5 younger adults.

CNA

COVID-19 survivors have twice the risk of developing dangerous blood clots that travel to their lungs compared to people who were not infected, as well double the chance of respiratory symptoms, a large new study said on Tuesday (May 24). The research by the Centers for Disease Control and Prevention (CDC) found that as many as one in five adults aged 18 to 64 and one in four of those over 65 went on to experience health conditions that could be related to their bout of COVID-19 - a finding consistent with other research.

Financial Express

Doctors at a Delhi government-run hospital have conducted a study to examine the epidemiological characteristics of the pandemic by describing clinical profiles of COVID-19 patients, and found that hypertension was the most common co-morbidity among them.

Voa News

The World Health Organization does not have evidence that the monkeypox virus has mutated, a senior executive at the U.N. agency said on Monday, noting the infectious disease that is endemic in west and central Africa has tended not to change.

Financial Express

Infection with the SARS-CoV-2 virus, which causes COVID-19, is associated with impaired function of the right side of the heart, according to a new study on intensive care patients in Scotland. The researchers from NHS Golden Jubilee and the University of Glasgow in Scotland noted that these findings could play a vital role in not only saving the lives of COVID-19 patients, but for the care of potentially fatal heart and lung issues generally.

ANI News

Infusions of the local anesthetic lidocaine may provide some pain relief to persons with chronic migraine who have failed to respond to other treatments, according to a recent study. The findings of the research were published in the journal 'Regional Anesthesia & Pain Medicine'.

The Print

Some antiviral medications might have the potential to shorten symptoms of monkeypox and reduce the amount of time a patient is contagious, according to a study of seven patients diagnosed with the rare viral disease in the UK between 2018 and 2021. The cases analysed in the study, published on Tuesday in The Lancet Infectious Diseases journal, represent the first instances of in-hospital transmission and household transmission outside of Africa.

News Logic

India’s ministry of health and family welfare will issue comprehensive guidelines later this week for the treatment and prevention of monkeypox amid an outbreak of the viral disease with nearly 100 confirmed cases globally. The decision was taken at a meeting held on Monday attended by officials from the Indian Council of Medical Research (ICMR), World Health Organization (WHO), National Centre for Disease Control (NCDC), clinicians and health ministry to firm up standard operating procedures for travellers who show symptoms of moneypox after returning from affected countries.

Health Services

Financial Express

Genes2Me announced on Monday the launch of its wide range of Next-generation sequencing (NGS)-based panels for oncology, personalised medicine, and hereditary diseases.

Live Mint

The Union Health Ministry and Indian Council of Medical Research (ICMR) have prepared standard treatment guidelines for at least 15 conditions of tuberculosis. This includes guidelines for pediatrics TB and extra pulmonary tuberculosis that occurs in organ systems other than the lungs. These guidelines will help doctors at the primary and secondary healthcare centers to get firsthand knowledge of TB treatment. According to union ministry of health and family welfare, India accounts for around 26  percent of the total TB cases across the world. It is still one of the most infectious killers, causing more deaths than malaria or AIDS.

Disclaimer: This news page has curated abstracts of daily healthcare news stories from various daily news outlets. To view the complete story, click on the link (provided with each news). Biological E Limited in collaboration with TodaySource has not verified these news stories and are not liable for the authenticity of the news.
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