News Bulletin
The baby was brought to Fortis Escorts Heart Institute, Okhla, in a serious condition with breathing difficulties, sepsis-like symptoms, heart failure signs, elevated heart rate, excessive perspiration, inability to feed, liver enlargement, and failure to gain weight. An echocardiogram revealed that the baby suffered from a hole in the heart, also known as patent ductus arteriosus (PDA) — a condition where an extra blood vessel is found in babies before birth and just after birth.
Amidst concerns over the outbreak of deadly virus infections like Nipah in Kerala, the state on Monday reported a rare case of recovery from amoebic meningoencephalitis, which has a 97 percent mortality rate. State Health Minister Veena George's office on Monday confirmed that it was a rare occurrence, which has a mortality rate of 97 percent and it is believed that only 11 persons in the world so far recovered from the infection. Earlier detection of the infection helped in speedy recovery of the boy. The minister also praise the efforts of the medical team that treated the boy.
For the first time, scientists have grown 3D brain models using cells from multiple people. The new hybrid creations, which researchers have dubbed "chimeroids," are a variation of brain organoids — tiny 3D models made of tissue that mimic the structure and function of a full-size brain. These models are more accurate to human biology than 2D cellular models or animals like lab mice. Because of this, scientists hope that the models will accelerate drug research and development.
Ten years ago, a scan showed that I had torn the meniscus in my knee. The pain was bad and I was limping a lot of the time. My doctor recommended arthroscopic knee surgery to fix it. Being scared of scalpels, I asked whether there were other options. He said I could try physiotherapy, but that it was unlikely to work. I tried the physio and did the recommended exercises diligently, and my knee pain and function returned to almost normal. I even ran my first (and only) marathon a year later.
A small farmer from a remote village walks into the nearest town’s health clinic. He breathes into a tube connected to a Vionix analyser. This device compares the farmer’s breath with hundreds of millions of other samples from around the world. An AI model, running on the cloud, identifies patterns of disease manifestations in the spectral signatures of the breath sample and instantly provides results on the farmer’s smartphone.
The first man to receive a genetically modified pig kidney transplant has died two months after the operation, the hospital which carried out the procedure has said. Richard "Rick" Slayman, 62, was suffering with end-stage kidney disease before undergoing the operation in March. Massachusetts General Hospital (MGH) said on Sunday there was no indication his death was a result of the transplant.
A girl born deaf can now hear unaided after participating in a world-first trial. The CHORD study is for children born with hearing loss due to a genetic condition called auditory neuropathy. Auditory neuropathy is a condition where the ear can detect sound normally, but has a problem sending signals to the brain.
A study found that one-third of patients receiving surgery for adult spinal deformity (ASD) also have severe hip osteoarthritis (OA), which can lead to poor spinal alignment and physical functionality. Findings of the study published in The Journal of Bone & Joint Surgery.
For the roughly 1.5 million Americans per year who survive a traumatic brain injury, health outcomes vary widely. Not only can these injuries lead to a loss of coordination, depression, impulsivity, and difficulty concentrating, but they come with an amplified risk for developing dementia in the future. The glaring absence of treatments for such a widespread condition drove a team of scientists at Gladstone Institutes to uncover, on a molecular level, how traumatic brain injuries trigger neurodegeneration—and just as importantly, how to target that process to prevent long-term damage.
Sanofi and SK bioscience have entered into a new chapter of their collaboration in pneumococcal vaccines with an expanded agreement to develop, license and commercialize next-generation PCVs for both pediatric and adult populations, reaffirming their commitment to fighting pneumococcal disease.
Drinking tea or coffee is associated with a lower risk of developing cancers of the head and neck, including cancers of the mouth and throat, according to a review of previously published studies. Drinking 3-4 cups of coffee daily was linked to a 17 percent lower risk of head and neck cancer, while consuming one cup of tea was associated with a 9 percent lower risk, according to the findings published in the journal Cancer. Previous research has shown that bioactive compounds in coffee and tea, such as caffeine, have anti-inflammatory and antioxidant properties which contribute to lowering disease risk. A recent study also suggested that coffee, in moderation, could promote healthy longevity.
Sapience Therapeutics announced that the first patient has been enrolled in its phase 2 dose expansion study evaluating ST316, the company’s first-in-class antagonist of ß-catenin. Enrollment of the study’s phase 1 monotherapy dose escalation portion was completed in July 2024.
Researchers have identified nearly 200 chemicals linked to breast cancer in food packaging materials and plastic tableware, with many capable of migrating into the human body. In a study published in ‘Frontiers in Toxicology’, they highlighted the presence of at least 189 potential breast carcinogens, including PFAS, bisphenols, and phthalates, in food contact materials (FCMs). Jane Muncke, study co-author, managing director and chief scientific officer at the Food Packaging Forum, a non-profit foundation based in Zurich, Switzerland said, “There is strong evidence that 76 known or potential breast carcinogens from food contact materials recently purchased all over the world can be found in people.”
British drugmaker GSK said on Wednesday its experimental herpes simplex virus (HSV) vaccine candidate failed to meet the main goal of a mid-stage trial and would not be taken forward to a late-stage trial.
A pooled analysis from the BOREAS and NOTUS phase 3 studies showed that Dupixent reduced exacerbations and improved lung function compared to placebo in adults with uncontrolled chronic obstructive pulmonary disease (COPD) and evidence of type 2 inflammation (i.e., raised blood eosinophils).
Positive results from the HERCULES phase 3 study showed that tolebrutinib, Sanofi’s oral brain-penetrant BTK inhibitor, met the primary endpoint of improvement over placebo in delaying time to onset of confirmed disability progression (CDP) in people with non-relapsing secondary progressive MS (nrSPMS).
This WHO Medical Product Alert refers to one batch of falsified Oxymorphone Hydrochloride 40mg. The falsified product was detected in the unregulated supply chain in Finland and reported to WHO in July 2024 by the Finnish Medicines Agency (FIMEA). Oxymorphone Hydrochloride is a semi-synthetic opioid used to treat moderate to severe pain. However, laboratory analysis of samples of the falsified product found that the tablets contained metonitazene instead.
Merck announced positive topline results from its phase 2b/3 clinical trial (MK-1654-004) evaluating clesrovimab (MK-1654), the company’s investigational prophylactic monoclonal antibody designed to protect infants from respiratory syncytial virus (RSV) disease.
Statins, a class of cholesterol-lowering drugs, have no effect on kidney function, a research team led by the University of Iowa has found. The research team, led by clinical professors Michelle Fravel and Michael Ernst, in the College of Pharmacy, examined the association between statin use in older adults and changes in two important indicators of kidney function -- estimated glomerular filtration rate and urine albumin-to-creatinine (protein-to-waste) ratio.
Patients with atrial fibrillation are typically prescribed an anticoagulant, or blood thinner, to reduce the risk of stroke, but many may discontinue them or never receive a prescription due to concerns of increased risk of bleeding complications. Researchers from Mass General Brigham evaluated a drug that represents a new class of anticoagulants known as Factor XI inhibitors for treating patients with atrial fibrillation as part of the AZALEA-TIMI 71 Study. The trial was stopped early by the recommendation of the Data Monitoring Committee due to an overwhelming reduction in bleeding compared to standard-of-care treatment. The researchers report in the New England Journal of Medicine that abelacimab, a Factor XI inhibitor, significantly reduced bleeding compared to a standard-of-care anticoagulant, rivaroxaban
Adults with overweight or obesity and type 2 diabetes who are given the sodium glucose cotransporter 2 (SGLT-2) inhibitor drug dapagliflozin alongside moderate calorie restriction achieve much higher rates of remission compared with calorie restriction alone, finds a trial published by The BMJ today. The researchers say this study provides a practical strategy to achieve remission for patients with early type 2 diabetes.
Antibiotics, antivirals, vaccinations and anti-inflammatory medication are associated with reduced risk of dementia, according to new research that looked at health data from over 130 million individuals.
Age-related macular degeneration (AMD) is the leading cause of vision loss in individuals over 65, characterized by abnormal changes in the macular, resulting in reduced vision and distorted objects. Dry AMD accounts for 90 percent of all AMD cases, with relatively mild vision impairment; however, approximately 30 percent progress to the severe vision loss associated with wet AMD within 10 years. The only FDA-approved treatments for dry AMD as of 2023 are two injectable drugs, which are limited by concerns over complications from intravitreal injections and modest efficacy in restoring vision.
A new RSV drug designed to protect young children was 93 percent effective at preventing hospitalization for the viral disease, a new study reports. Furthermore, the drug was 89 percent effective at preventing all types of doctor visits for RSV, which is short for "respiratory syncytial virus."
Kumamoto University scientists have unveiled a novel compound, HPH-15, with dual effects of reducing blood glucose levels and combating fat accumulation, marking a significant leap in diabetes treatment innovation. Type 2 diabetes, a condition affecting millions worldwide, is often accompanied by complications like fatty liver and insulin resistance, which challenge current treatment methods.
Effective immunity hinges on the ability to sense infection and cellular transformation. In humans, there is a specialized molecule on the surface of cells termed MR1. MR1 allows sensing of certain small molecule metabolites derived from cellular and microbial sources; however, the breadth of metabolite sensing is unclear.
Already the go-to drug of choice for millions with type 2 diabetes, metformin might also fight lung cancer if those patients have it as well, new research shows. Metformin appears to help boost the benefits of immunotherapy drugs used to fight lung tumors, according to a team led by Dr. Sai Yendamuri. He directs thoracic surgery at Roswell Park Comprehensive Cancer Center in Buffalo, N.Y.
Biological E Limited's Corbevax is being administered to children in the age group 12-14 in India. This age group got the Indian government's nod to be receive vaccine against the novel coronavirus from 16 March, Wednesday. These children have to register for getting the vaccine on the CoWIN portal. India's third indigenous anti-Covid vaccine has been manufactured by Hyderabad-based Biological E Limited. Biological E has supplied 5 crore doses of Corbevax to the Centre, which has then distributed the same to states.
Biological E seems confident regarding getting emergency use authorisation for use of its COVID vaccine Corbevax among children in the age group of 5-12 years. Currently, the vaccine is inoculated among children in the age group of 12 to 14 years The Hyderabad-based company Is qualified to produce around 1 billion dosages of Corbevax annually and it is geared up to meet any increase in demand. Currently, the company has produced 30 crore vaccines as part of its commitment made to the Government of India, with 5 crore dosages already supplied.
Biotech firm Biological E. Limited is geared to facilitate the first phase of the vaccination drive for the 12-15 age group and is ready with 30 crore doses of which five crore has been rolled out to 17 different sites in the country, said a top official of the firm. "This is the most affordable COVID-19 vaccine for the Government of India which is providing free vaccination to all eligible citizens. The pricing of CORBEVAX in the private market will be Rs 800 (and inclusive of all taxes and vaccine administration charges will cost Rs 990) The vaccine is being sold at Rs 145 per dose to the government," Mahima Datla, managing director of Biological E. Limited said at a virtual media interaction on Wednesday. "We have an annual production capacity upto one billion vaccines," Datla said. The firm collaborated with the Texas Children's Hospital and the Baylor College to develop Corbevax vaccine. Dynavax, Inc from USA supported Corbevax development by providing the adjuvant and THSTI Delhi conducted key immunogenicity testing as part of a comprehensive clinical trial development plan.
Only about 3,800 children aged between 12 and 14 were vaccinated against Covid-19 in the city on Wednesday, the first day of vaccination for this cohort in the country. All the children were administered Corbevax, India's first indigenously developed protein subunit vaccine against Covid-19, made by Biological E. Each dose in the private market will cost Rs 800 per dose, excluding GST, and around Rs 990, including taxes and administration charges. For the government, the price will be Rs 145. There are nearly 6.2 lakh children in this age group in Delhi who are eligible for the vaccine. Hospital officials said the first day saw a lukewarm response; footfall is expected to pick up after Holi.
The baby was brought to Fortis Escorts Heart Institute, Okhla, in a serious condition with breathing difficulties, sepsis-like symptoms, heart failure signs, elevated heart rate, excessive perspiration, inability to feed, liver enlargement, and failure to gain weight. An echocardiogram revealed that the baby suffered from a hole in the heart, also known as patent ductus arteriosus (PDA) — a condition where an extra blood vessel is found in babies before birth and just after birth.
Amidst concerns over the outbreak of deadly virus infections like Nipah in Kerala, the state on Monday reported a rare case of recovery from amoebic meningoencephalitis, which has a 97 percent mortality rate. State Health Minister Veena George's office on Monday confirmed that it was a rare occurrence, which has a mortality rate of 97 percent and it is believed that only 11 persons in the world so far recovered from the infection. Earlier detection of the infection helped in speedy recovery of the boy. The minister also praise the efforts of the medical team that treated the boy.
For the first time, scientists have grown 3D brain models using cells from multiple people. The new hybrid creations, which researchers have dubbed "chimeroids," are a variation of brain organoids — tiny 3D models made of tissue that mimic the structure and function of a full-size brain. These models are more accurate to human biology than 2D cellular models or animals like lab mice. Because of this, scientists hope that the models will accelerate drug research and development.
Ten years ago, a scan showed that I had torn the meniscus in my knee. The pain was bad and I was limping a lot of the time. My doctor recommended arthroscopic knee surgery to fix it. Being scared of scalpels, I asked whether there were other options. He said I could try physiotherapy, but that it was unlikely to work. I tried the physio and did the recommended exercises diligently, and my knee pain and function returned to almost normal. I even ran my first (and only) marathon a year later.
A small farmer from a remote village walks into the nearest town’s health clinic. He breathes into a tube connected to a Vionix analyser. This device compares the farmer’s breath with hundreds of millions of other samples from around the world. An AI model, running on the cloud, identifies patterns of disease manifestations in the spectral signatures of the breath sample and instantly provides results on the farmer’s smartphone.
The first man to receive a genetically modified pig kidney transplant has died two months after the operation, the hospital which carried out the procedure has said. Richard "Rick" Slayman, 62, was suffering with end-stage kidney disease before undergoing the operation in March. Massachusetts General Hospital (MGH) said on Sunday there was no indication his death was a result of the transplant.
A girl born deaf can now hear unaided after participating in a world-first trial. The CHORD study is for children born with hearing loss due to a genetic condition called auditory neuropathy. Auditory neuropathy is a condition where the ear can detect sound normally, but has a problem sending signals to the brain.
A study found that one-third of patients receiving surgery for adult spinal deformity (ASD) also have severe hip osteoarthritis (OA), which can lead to poor spinal alignment and physical functionality. Findings of the study published in The Journal of Bone & Joint Surgery.
For the roughly 1.5 million Americans per year who survive a traumatic brain injury, health outcomes vary widely. Not only can these injuries lead to a loss of coordination, depression, impulsivity, and difficulty concentrating, but they come with an amplified risk for developing dementia in the future. The glaring absence of treatments for such a widespread condition drove a team of scientists at Gladstone Institutes to uncover, on a molecular level, how traumatic brain injuries trigger neurodegeneration—and just as importantly, how to target that process to prevent long-term damage.
Researchers have utilized artificial intelligence to develop a framework for creating a vaccine designed to train the immune system to combat cancer. The approach focuses on leveraging AI technology to identify and target specific mechanisms within the body that could enhance its ability to fight aggressive forms of skin cancer.
For a majority of people, the COVID vaccine doesn’t cause adverse health effects — but a small percentage experience chronic symptoms that can last for months or even years. Yale researchers recently made some discoveries about why certain people experience this condition, which they have dubbed "post-vaccination syndrome" (PVS). In early findings, the team recognized "potential immunological patterns" that are unique to people with PVS. The hope is that this discovery will help to enable future treatments and therapies for those who are affected.
Memorial Sloan Kettering Cancer Center researchers have found RNA neoantigen vaccines that generate long-lived, functional CD8+ T cells in patients with pancreatic ductal adenocarcinoma (PDAC), potentially delaying disease recurrence. PDAC is a lethal cancer with limited treatment options and a low mutational burden. T cells defend the body by destroying harmful outside pathogens and mutated body cells, such as cancer.
A new study has found a major drop in respiratory syncytial virus (RSV) related hospitalisations following vaccination among eligible age groups in Scotland. The study, from Public Health Scotland (PHS) and the University of Strathclyde, showed a 62 percent reduction in RSV-related hospitalisations among those who received the vaccine and concludes the vaccine is effective in reducing such hospitalisations in older adults.
India is looking at several potential vaccine candidates for deployment in the tuberculosis elimination programme with the Indian Council for Medical Research testing the BCG vaccine for TB control. ICMR chief and secretary health research Rajiv Bahl said the BCG vaccine, currently administered to children, was being tested in adults vulnerable to TB. The Bacillus Calmette-Guérin (BCG) vaccine is given to children at risk of tuberculosis (TB). It's a common vaccine in countries where TB is prevalent. India houses nearly one fourth of the global TB-affected people and has a target of elimination of the disease by 2025.
India plans to roll out the HPV vaccine in the national immunization programme for school girls to protect them from cervical cancer “in a few months” time, top health ministry officials said Tuesday. “The HPV vaccine will be rolled out in a few months but we will have to wait for the TB vaccine,” said Union Health Secretary Punya Salila Srivastava at a press conference held by Union Health Minister J P Nadda. Without giving any more details, she said, the ministry is strategizing the way forward. Cervical cancer, which is the second most common cancer in India, is a preventable and curable disease if detected early and treated adequately. Cervical cancer is a significant public health challenge in India, accounting for 77,348 cervical cancer deaths in women, annually.
While COVID-19 vaccination decreases the severity of COVID-19 disease and the rate of hospitalisation and death, a study published recently has found that vaccination prior to SARS-CoV-2 infection does not necessarily reduce the neurological manifestations and burden of Long COVID. This includes patients who had a severe infection that necessitated hospitalisation and those with a mild infection who did not require hospitalisation. Common neurological symptoms of Long COVID include brain fog, numbness and tingling, headache, dizziness, problems with smell and taste, and intense fatigue.
Johns Hopkins Medicine researchers have shown that people 60 years or older with weakened immunity—primarily organ transplant recipients who take immunosuppressive medications to reduce the risk of rejection and others with immune system disorders—do not respond as strongly to vaccines against the respiratory syncytial virus (RSV) as people in the same age group with normal immune function.
Serum Institute of India (SII) has entered into an exclusive licence agreement with French speciality vaccine company Valneva SE to manufacture and sell Valneva’s chikungunya vaccine in India and the rest of Asia. Valneva’s chikungunya vaccine is the world’s first and only licensed vaccine. It is currently approved in the US, Europe, and Canada for adults. Regulatory reviews are underway to expand it to children up to 12 years.
Brazilian researchers have developed a simple test that almost instantly tells whether a person has been exposed to any of the four dengue virus serotypes, as well as Zika virus. The test is an enzyme immunoassay similar to ELISA, a platform widely used in laboratory testing throughout Brazil. The technology can easily be adapted for use in automated systems and rapid point-of-care tests. The study was conducted at the University of São Paulo's Biomedical Sciences Institute (ICB-USP) in partnership with researchers at the same university's medical school (FM-USP), and collaborators at the Federal University of West Bahia (UFOB) led by Jaime Henrique Amorim. An article reporting the findings is published in the Journal of Medical Virology.
Researchers from the Max Planck Institute of Biochemistry have discovered the mechanism behind an important step in the life cycle of HIV. Working together with teams at Heidelberg and Yale Universities, they found that the enigmatic "spacer peptide 2," one of the virus components, plays a key role in converting immature HIV-1 particles into infectious particles. The results of the study were published in the journal Nature.
Nearly 25 lakh people over the age of 30 have been diagnosed with hypertension, and around 12 lakh people have been identified with diabetes in Telangana through regular screenings under the NP-NCD.
The first cases of avian influenza virus (H5N1) in domestic cats in India were reported from Chhindwara district in Madhya Pradesh, raising concerns about the bird flu pathogen mutating and infecting humans.
Researchers at The Wistar Institute's HIV Cure and Viral Diseases Center have successfully identified a new approach using natural killer (NK) cells to target and kill the HIV-positive cells that allow the virus to persist. Wistar scientists have labeled this new approach "NuKES": Natural Killer Enhancement Strategy.
Pancreatic cancer (PC) is the worst prognosis cancer globally, with just 13 percent of patients who are diagnosed with PC surviving for 5 years or more after initial diagnosis. In Ireland, there are approximately 900 cases of PC per year, and 820 PC-related deaths. Early detection of PC is the primary concern of most PC research, as it has the potential to make a substantial difference to the treatment and survival of patients
A study reveals that traumatic brain injury alters the small vessels in the brain, resulting in an accumulation of amyloid beta -- a hallmark of Alzheimer's disease. The findings suggest that vascular dysfunction could be an early driver in neurodegenerative disorders rather than being caused by neuronal damage.
A COVID-19 diagnosis is no longer as frightening as it used to be, thanks to developments in treatment choices. However, a new study reveals that leukocyte (white blood cell) count may now be used to identify who is more likely to develop more significant disease symptoms.
The bacteria Campylobacter jejuni (C. jejuni) is being believed to be the cause behind the outbreak of Guillain-Barre Syndrome (GBS) in the regions of Maharashtra, mainly Pune, official sources said on Thursday. They said that bacteria Campylobacter jejuni has been found in 20-30 percent of the samples taken from the GBS positive cases. GBS mostly is a post-infection syndrome, which usually manifests itself two to six weeks after a person gets an infection. "Lot of samples have been taken and are being tested at the NIV Pune. Bacteria Campylobacter jejuni has been found in 20-30 percent of the samples taken from GBS positive cases and is believed to be the cause. But investigations are still on," a source said.
A vaccine to fight cancers affecting women will be available in five to six months, and those in the age group of 9 to 16 years will be eligible for inoculation, Union Minister Prataprao Jadhav said on Tuesday. The Union Minister of State for Health, Family Welfare and Ayush (Independent Charge) said that research on a vaccine is nearly complete and trials are underway. "The number of cancer patients has increased in the country, and the central government has initiated steps to address this issue. Women above 30 will undergo screening at hospitals, and daycare cancer centres will be established for early detection of the disease," Jadhav said.
Under the leadership of Chief Minister Yogi Adityanath, state-of-the-art arrangements are being meticulously planned for the upcoming Maha Kumbh to welcome devotees from across India and abroad. Among the latest initiatives, the government is set to introduce artificial intelligence (AI) in Intensive Care Units, aiming to enhance the quality of patient care and ensure a superior healthcare experience during the event. Being deployed for the first time within the Mela grounds, the advanced AI messaging flow system is capable of interpreting and conveying the concerns of patients from any part of the country or the world to doctors.
It has been identified that the 38-year-old man from Edavanna in Malappuram--who is under treatment for mpox--is infected with the Clade 1b strain of the virus, making him the first such case in the country. Top officials of the health department were tight-lipped about the test result. A statement from Health Minister Veena George regarding the test result is expected on Tuesday. She has convened a meeting of a state-level Rapid Response Team (RRT) to assess the situation when mpox cases increase. Clade 1b strain of the virus is more infectious than Clade 2 and it is currently behind the global outbreak.
Recognizing the urgent need for a broad-based effort globally to reduce errors in medical diagnosis, the World Health Organization (WHO) is calling on all stakeholders to “Get it right, make it safe!” as part of the World Patient Safety Day campaign on 17th September. The theme ‘improving diagnosis for patient safety’ was selected in consultation with a wide range of stakeholders – from patients to policy-makers – to highlight how everyone has a vital role to play in reducing the risks and impact of errors in diagnosis.
National Institute of Mental Health and Neuro Sciences (NIMHANS) is ensuring to make mental health care more relatable and accessible. The Institute which plays a crucial role in challenging mental health stigma and advocating for a society that prioritizes mental well-being is making to normalize conversations about mental health.
Under the vision of the Prime Minister to rid the country of TB by 2025, five years ahead of the global target for eliminating the disease under the Sustainable Development Goals, the Union Ministry of Health and Family Welfare has approved the introduction of the BPaLM regimen, an official statement said. The BPaLM regimen is a novel treatment for multi-drug-resistant tuberculosis (MDR-TB) under its National TB Elimination Programme (NTEP) as a highly effective and shorter treatment option.
Of the over 47 million digital out-patient department (OPD) registrations under the National Health Authority’s (NHA’s) ‘scan and share’ service in the last two years, 12.4 million OPD tokens were generated by Uttar Pradesh alone.
KITES Senior Care, a division of Lifebridge Senior Care, founded by Rajagopal G, Dr A S Arvind, and Dr Reema Nadig, has launched a new Geriatric Care Centre on Kanakapura Road, Bengaluru. The centre will offer seniors, personalised transitional and rehab care to support their recovery after surgery, palliative and hospice care focused on comfort and pain management, and dependable respite care.
Noida-based startup Redcliffe Labs, a purpose-driven PAN India diagnostic service provider, has announced the launch of its advanced MPOX testing capabilities, reinforcing its commitment to national health security. This strategic move is a significant step towards bolstering the nation’s preparedness against potential MPOX outbreaks.
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